Expression analysis of novel striatal-enriched genes in Huntington disease
Identifieur interne : 001B32 ( Main/Exploration ); précédent : 001B31; suivant : 001B33Expression analysis of novel striatal-enriched genes in Huntington disease
Auteurs : Gelareh Mazarei [Canada] ; Scott J. Neal [Canada] ; Kristina Becanovic [Canada] ; Ruth Luthi-Carter [Suisse] ; Elizabeth M. Simpson [Canada] ; Blair R. Leavitt [Canada]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2010-02-15.
Abstract
Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mouse models exhibiting striatal degeneration, have demonstrated changes in the expression of many important genes with a large proportion of changes being observed in the striatal-enriched genes. These investigations have raised questions about how enrichment of particular transcripts in the striatum can lead to its selective vulnerability to neurodegeneration. Monitoring the expression changes of striatal-enriched genes during the course of the disease may be informative about their potential involvement in selective degeneration. In this study, we analyzed a Serial Analysis of Gene Expression (SAGE) database (www.mouseatlas.org) and compared the mouse striatum to 18 other brain regions to generate a novel list of striatal-enriched transcripts. These novel striatal-enriched transcripts were subsequently evaluated for expression changes in the YAC128 mouse model of HD, and differentially expressed transcripts were further examined in human post-mortem caudate samples. We identified transcripts with altered expression in YAC128 mice, which also showed consistent expression changes in human post-mortem tissue. The identification of novel striatal-enriched genes with altered expression in HD offers new avenues of study, leading towards a better understanding of specific pathways involved in the selective degeneration of striatal neurons in HD.
Url:
DOI: 10.1093/hmg/ddp527
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002914
- to stream Istex, to step Curation: 002914
- to stream Istex, to step Checkpoint: 000517
- to stream Main, to step Merge: 001C45
- to stream Main, to step Curation: 001B32
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Expression analysis of novel striatal-enriched genes in Huntington disease</title><author><name sortKey="Mazarei, Gelareh" sort="Mazarei, Gelareh" uniqKey="Mazarei G" first="Gelareh" last="Mazarei">Gelareh Mazarei</name></author><author><name sortKey="Neal, Scott J" sort="Neal, Scott J" uniqKey="Neal S" first="Scott J." last="Neal">Scott J. Neal</name></author><author><name sortKey="Becanovic, Kristina" sort="Becanovic, Kristina" uniqKey="Becanovic K" first="Kristina" last="Becanovic">Kristina Becanovic</name></author><author><name sortKey="Luthi Carter, Ruth" sort="Luthi Carter, Ruth" uniqKey="Luthi Carter R" first="Ruth" last="Luthi-Carter">Ruth Luthi-Carter</name></author><author><name sortKey="Simpson, Elizabeth M" sort="Simpson, Elizabeth M" uniqKey="Simpson E" first="Elizabeth M." last="Simpson">Elizabeth M. Simpson</name></author><author><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B0FDF3D69C012447AAD76BC2AD49A37D1D6EFD13</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/hmg/ddp527</idno><idno type="url">https://api-v5.istex.fr/document/B0FDF3D69C012447AAD76BC2AD49A37D1D6EFD13/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002914</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002914</idno><idno type="wicri:Area/Istex/Curation">002914</idno><idno type="wicri:Area/Istex/Checkpoint">000517</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000517</idno><idno type="wicri:doubleKey">0964-6906:2010:Mazarei G:expression:analysis:of</idno><idno type="wicri:Area/Main/Merge">001C45</idno><idno type="wicri:Area/Main/Curation">001B32</idno><idno type="wicri:Area/Main/Exploration">001B32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Expression analysis of novel striatal-enriched genes in Huntington disease</title><author><name sortKey="Mazarei, Gelareh" sort="Mazarei, Gelareh" uniqKey="Mazarei G" first="Gelareh" last="Mazarei">Gelareh Mazarei</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Neal, Scott J" sort="Neal, Scott J" uniqKey="Neal S" first="Scott J." last="Neal">Scott J. Neal</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Becanovic, Kristina" sort="Becanovic, Kristina" uniqKey="Becanovic K" first="Kristina" last="Becanovic">Kristina Becanovic</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Luthi Carter, Ruth" sort="Luthi Carter, Ruth" uniqKey="Luthi Carter R" first="Ruth" last="Luthi-Carter">Ruth Luthi-Carter</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Brain Mind Institute, cole Polytechnique Fdrale de Lausanne (EPFL), Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Simpson, Elizabeth M" sort="Simpson, Elizabeth M" uniqKey="Simpson E" first="Elizabeth M." last="Simpson">Elizabeth M. Simpson</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="609">609</biblScope><biblScope unit="page" to="622">622</biblScope></imprint><idno type="ISSN">0964-6906</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mouse models exhibiting striatal degeneration, have demonstrated changes in the expression of many important genes with a large proportion of changes being observed in the striatal-enriched genes. These investigations have raised questions about how enrichment of particular transcripts in the striatum can lead to its selective vulnerability to neurodegeneration. Monitoring the expression changes of striatal-enriched genes during the course of the disease may be informative about their potential involvement in selective degeneration. In this study, we analyzed a Serial Analysis of Gene Expression (SAGE) database (www.mouseatlas.org) and compared the mouse striatum to 18 other brain regions to generate a novel list of striatal-enriched transcripts. These novel striatal-enriched transcripts were subsequently evaluated for expression changes in the YAC128 mouse model of HD, and differentially expressed transcripts were further examined in human post-mortem caudate samples. We identified transcripts with altered expression in YAC128 mice, which also showed consistent expression changes in human post-mortem tissue. The identification of novel striatal-enriched genes with altered expression in HD offers new avenues of study, leading towards a better understanding of specific pathways involved in the selective degeneration of striatal neurons in HD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Suisse</li></country><region><li>Canton de Vaud</li></region><settlement><li>Lausanne</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Mazarei, Gelareh" sort="Mazarei, Gelareh" uniqKey="Mazarei G" first="Gelareh" last="Mazarei">Gelareh Mazarei</name></noRegion><name sortKey="Becanovic, Kristina" sort="Becanovic, Kristina" uniqKey="Becanovic K" first="Kristina" last="Becanovic">Kristina Becanovic</name><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name><name sortKey="Neal, Scott J" sort="Neal, Scott J" uniqKey="Neal S" first="Scott J." last="Neal">Scott J. Neal</name><name sortKey="Simpson, Elizabeth M" sort="Simpson, Elizabeth M" uniqKey="Simpson E" first="Elizabeth M." last="Simpson">Elizabeth M. Simpson</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Luthi Carter, Ruth" sort="Luthi Carter, Ruth" uniqKey="Luthi Carter R" first="Ruth" last="Luthi-Carter">Ruth Luthi-Carter</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B0FDF3D69C012447AAD76BC2AD49A37D1D6EFD13
|texte= Expression analysis of novel striatal-enriched genes in Huntington disease
}}
| This area was generated with Dilib version V0.6.29. |  |